Naoussa rests on the foothills of the Vermio Mountains where Dionysus, the god of wine himself dwelt. He or the ancient Greeks perceived something about wine in the region to merit his presence there and maybe, who knows, even blessed the origins of viniculture itself!
In modern times, the first recorded evidence of viniculture dates back to 1700, where its reputation spread far and wide for being the best wine in the Ottoman Empire. At that time, the Xinomavro, Negoska, Naousseiko, Sefka, Prekniariko, and other varieties of grapes were cultivated in the area's vineyards.
Naoussa was where the first modern Greek wine was bottled in 1905, the famous "Naoussa Boutari", while in 1971 the wine-growing region of Naoussa was identified as a Protected Destination of Origin (PDO) region.